Chelsea are currently battling for a top-four spot in the Premier League, while they only won three of their six group matches to make the knockout stage of this season's Champions League.
Barcelona, on the other hand, are flying high at the top of La Liga, and breezed through their group unbeaten to make the round of 16.
Stay tuned for live minute-by-minute updates of the action.
CHELSEA: Courtois; Rudiger, Christensen, Azpilicueta; Moses, Kante, Fabregas, Alonso; Willian, Hazard, Pedro
BARCELONA: Ter Stegen; Roberto, Pique, Umtiti, Alba; Busquets, Rakitic, Iniesta, Paulinho; Messi, Suarez