There is plenty on the line in the 170th league encounter between these arch-rivals, who are separated by just two points in the race for second place.
The last four meetings have finished all square, but it is United who edge things overall with 67 wins to the Reds' 55, dating back to the first clash well over a century ago.
Follow all of the action as it unfolds with our extensive updates below.
26 min Many have questioned why Rashford has not started more games this season - the opening 26 minutes have done little to quiet those queries. Yet another brilliantly composed finish from the Englishman, tucking home a loose ball after Lukaku's through-ball was cut out. Two chances, two goals - game over?
25 min GOAL! MANCHESTER UNITED 2-0 LIVERPOOL (MARCUS RASHFORD)
24 min CHANCE! Good defending from Valencia to cut out a pass intended for Firmino around the back. From the resulting corner, Van Dijk fails to find the target from five yards. Under pressure from Matic, he could only meet the cross with his shoulder and not his head.
22 min A quarter of the way through what has been a quiet contest, with Rashford's well-taken strike 14 minutes in proving to be the only piece of quality thus far. Klopp will not be too concerned at the moment; still plenty of time to turn things around.
20 min Man United have taken the lead in 352 previous home games and lost just three of them, most recently to Liverpool. Still just the one shot of any sort at Old Trafford this afternoon, leading to the game's breakthrough goal.
18 min Firmino does well to keep the ball in play when many had fallen asleep. The Brazilian sent a decent delivery into the box, too, with the ball inches above the head of Mane at the back post. Up the other end, Robertson gets across to deny Rashford.
16 min That was the first shot of any sort in that match, with the finish belying the quality of the contest up until that point. Alexander-Arnold should have done better, being bullied by Rashford after finding himself slightly out of position.
14 min What a finish from Marcus Rashford! The Englishman may have been frustrated by a lack of minutes over the past couple of months, but there is no way Mourinho can leave him out on the basis of this goal. Lukaku with the flick-on, allowing Rashford to nod the ball forward, before cutting inside on his right and bending it out of Karius's reach - goal number five of the Premier League campaign.
13 min GOAL! MANCHESTER UNITED 1-0 LIVERPOOL (MARCUS RASHFORD)
11 min Rashford unlucky after getting to the ball first but failing to keep it in play. Both sides struggling to really keep a hold of the ball so far, but in many ways that is what many expected due to the tension that comes with this fixture.
9 min Firmino attempts to find Mane through the middle when he had Salah breaking down the right - bad choice. Looking at the possession stats, the visitors have seen three-quarters of the ball in the early stages here, which is quite surprising.
7 min Not a lot to report back on in the opening seven minutes of the contest. Liverpool had a turn bossing possession and now United are doing likewise, with neither side able to really get the ball into the final third of the field.
5 min That game has yet to really settle down, but that was to be expected in a fixture of this magnitude. Liverpool now being allowed to knock the ball around just inside the United half; the big question is whether they can feed Salah, Firmino and Mane.
3 min Sanchez attempts to close down Liverpool's centre-backs but soon realises he is on his own in doing so. The Chilean then appeared to ask his teammates whether they were going to push up high or allow the Reds to pass it around - strange.
1 min KICKOFF! Great atmosphere inside Old Trafford for this 170th league meeting between Manchester United and Liverpool. In case you were unaware, these two teams quite simply do not like each other! What an afternoon we are in store for.