Atletico carry a 1-1 draw and an away goal into the second leg at the Wanda Metropolitano.
Defeat for Arsenal would mean them missing out on Champions League qualification for a second season in a row, just as Wenger calls time on his 22 years in charge.
Simeone however said there would be no room for emotions when his players take to the field.
“We are not thinking about Wenger’s last season at Arsenal, only about what we need.
“We need to see a full stadium, the excitement of our players, the energy in the team, that’s what matters to us,” he told reporters on Wednesday.
Simeone was sent to the stands in the first leg and the feisty Argentinian will serve a touchline ban in the second leg.
“I’ll take it badly,” Simeone said.
“I’m sad about this situation and I’ll have to improve. I better shut up.”